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Zebularine

Zebularine

Item no.	HY-13420-5mg
Manufacturer	MedChem Express
CASRN	06.10.3690
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.99
Citations	[1]Champion C, et al. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One. 2010 Aug 24;5(8):e12388.\|[2]Cheng JC, et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst. 2003 Mar 5;95(5):399-409.\|[3]Billam M, et al. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res Treat. 2010 Apr;120(3):581-92.\|[4]Lemaire M, et al. Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine. Cancer Chemother Pharmacol. 2009 Feb;63(3):411-6.
Smiles	OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=CC=C2)=O)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NSC309132,4-Deoxyuridine
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; DNA Methyltransferase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	228.20
Product Description	Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. Zebularine also inhibits cytidine deaminase with a Ki of 0.95 μM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 100 mg/mL\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; Epigenetics
Isoform	DNMT1; DNMT3
Clinical information	No Development Reported

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HY-13420-5mg-safety-datasheet.pdf