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D-Saccharic acid 1,4-lactone (hydrate)

D-Saccharic acid 1,4-lactone (hydrate)

Item no.	HY-134453A-10mg
Manufacturer	MedChem Express
CASRN	61278-30-6
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.0
Formula	C6H10O8
Citations	[1]Taha M, et al. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs. Bioorg Chem. 2016;68:56-63. [2]Bhattacharya S, et al. Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. J Biochem Mol Toxicol. 2011;25(6):341-354. [3]Bhattacharya S, et al. D-saccharic acid-1,4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic β-cells from apoptosis via mitochondrial dependent pathway. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):272-83.
Smiles	OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O.O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	210.14
Product Description	D-Saccharic acid 1, 4-lactone hydrate is an orally active β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1, 4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1, 4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Manufacturer - Pathway	Apoptosis
Clinical information	No Development Reported

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HY-134453A-10mg-safety-datasheet.pdf