653-47

Item no.	HY-134598-50mg
Manufacturer	MedChem Express
CASRN	1224678-75-4
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
Smiles	O=C(C1=C(OCCCN)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1224678-75-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Epigenetic Reader Domain
Shipping Temperature	Room temperature
Molecular Weight	370.83
Product Description	653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Epigenetics
Clinical information	No Development Reported

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