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Rupatadine-d4 (fumarate)

Rupatadine-d4 (fumarate)

Item no.	HY-13511AS-10mg
Manufacturer	MedChem Express
CASRN	1795153-63-7
Amount	10 mg
Quantity options	10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Citations	[1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21.\|[2]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60.\|[3]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.
Smiles	CC1=CN=CC(CN2C([2H])([2H])C/C(CC2([2H])[2H])=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1.OC(/C=C/C(O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	UR-12592 D4 (fumarate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; Histamine Receptor; Isotope-Labeled Compounds
Shipping Temperature	Room temperature
Molecular Weight	536.05
Product Description	Rupatadine-d4 fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes)[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Isoform	H1 Receptor
Clinical information	No Development Reported

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Amount: 10 mg

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