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Nifurpirinol

Nifurpirinol

Item no.	HY-135470-50mg
Manufacturer	MedChem Express
CASRN	13411-16-0
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.70
Citations	[1]Bergemann D, et al. Nifurpirinol: A more potent and reliable substrate compared to metronidazole for nitroreductase-mediated cell ablations. Wound Repair Regen. 2018 Mar;26(2):238-244.\|[2]Klawitter M, Siegerist F, Daniel S, et al. Nifurpirinol: A potent inducer of FSGS-like glomerular injury in transgenic zebrafish[J]
Smiles	OCC1=NC(/C=C/C2=CC=C([N+]([O-])=O)O2)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	P-7138
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Bacterial
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	246.22
Product Description	Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS)[1][2].
Manufacturer - Research Area	Infection
Solubility	DMSO: ≥ 20.83 mg/mL
Manufacturer - Pathway	Anti-infection
Clinical information	No Development Reported

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HY-135470-50mg-safety-datasheet.pdf