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NHC-triphosphate (tetraammonium)

NHC-triphosphate (tetraammonium)

Item no.	HY-135867E-5mg
Manufacturer	MedChem Express
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	97.09
Dry ice	Yes
Citations	[1]Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.\|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus. bioRxiv. 2021 Jul 21:2021.07.21.453274. \|Nat Struct Mol Biol. 2021 Sep;28(9):740-746. \|ACS Bio Med Chem Au. October 24, 2022.\|Commun Biol. 2022 Feb 22;5(1):154.\|J Biol Chem. 2021 May 11;100770.\|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.\|ACS Sens. 2022 May 27;7(5):1564-1571.
Smiles	O[C@H]1[C@H](N(C=C/C2=N/O)C(N2)=O)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1O.N.N.N.N
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Dry ice
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	Endogenous Metabolite; Enterovirus; HCV; SARS-CoV; Topoisomerase
Shipping Temperature	Dry Ice
Storage Conditions	-80°C, protect from light, stored under nitrogen
Molecular Weight	567.28
Product Description	NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form[1]. NHC-triphosphate tetraammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2].
Manufacturer - Research Area	Infection
Solubility	DMSO: < 1 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-135867E-5mg-safety-datasheet.pdf