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Daminozide

Daminozide

Item no.	HY-13643-500mg
Manufacturer	MedChem Express
CASRN	1596-84-5
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.79
Citations	[1]Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43.\|[2]Roy SS, et, al. Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organism Drosophila melanogaster. Interdiscip Toxicol. 2018 May;11(1):27-37.
Smiles	O=C(NN(C)C)CCC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1596-84-5
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Histone Demethylase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	160.17
Product Description	Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 106.67 mg/mL (warming)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics
Isoform	KDM2
Clinical information	No Development Reported

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HY-13643-500mg-safety-datasheet.pdf