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Fludarabine triphosphate trisodium

Fludarabine triphosphate trisodium

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	1mg
Item no.	HY-136650A-1mg
Available
Product Description	Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Cancer-programmed cell death
Formula	C10H12FN5Na3O13P3
References	[1].Catapano CV, et al. Inhibition of primer RNA formation in CCRF-CEM leukemia cells by fludarabine triphosphate. Cancer Res. 1991 Apr 1; 51(7):1829-35. \| [2].Woodahl EL, et al. A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patients. Cancer Chemother Pharmacol. 2009 Feb; 63(3):391-401.
MolecularWeight	591.12
Research Area	Cancer
Target	Nucleoside Antimetabolite/Analog; Drug Metabolite; DNA/RNA Synthesis; Apoptosis
Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 1mg

available

Delivery expected until 4/13/2023

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