Comparison

GNE-9815 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 5mg
Item no. HY-142160-5mg
CASRN 2729996-45-4
Available
Product Description
GNE-9815 (compound 7) is a highly selective, pan-RAF inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for CRAF and BRAF, respectively. GNE-9815 combines with MEK inhibitor Cobimetinib (HY-13064) shows synergistic modulation of MAPK pathway. GNE-9815 can be used in studies of KRAS mutant cancers.
StorageTemperature
Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications
Cancer-Kinase/protease
Formula
C26H22FN5O2
References
[1].Huestis MP, et al. Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor. ACS Med Chem Lett. 2021 Apr 21; 12(5):791-797.
MolecularWeight
455.48
Research Area
Cancer
Solubility
DMSO : 50 mg/mL (109.77 mM; ultrasonic and warming and heat to 80°C)
Target
Raf
Isoform
CRAF; Braf
Pathway
MAPK/ERK Pathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 5mg
Available: In stock
available

Delivery expected until 4/6/2023 

Compare

Add to wishlist

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close