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GNE-9815

GNE-9815

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-142160-5mg
CASRN	2729996-45-4
Available
Product Description	GNE-9815 (compound 7) is a highly selective, pan-RAF inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for CRAF and BRAF, respectively. GNE-9815 combines with MEK inhibitor Cobimetinib (HY-13064) shows synergistic modulation of MAPK pathway. GNE-9815 can be used in studies of KRAS mutant cancers.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-Kinase/protease
Formula	C26H22FN5O2
References	[1].Huestis MP, et al. Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor. ACS Med Chem Lett. 2021 Apr 21; 12(5):791-797.
MolecularWeight	455.48
Research Area	Cancer
Solubility	DMSO : 50 mg/mL (109.77 mM; ultrasonic and warming and heat to 80°C)
Target	Raf
Isoform	CRAF; Braf
Pathway	MAPK/ERK Pathway

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Amount: 5mg

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Delivery expected until 4/6/2023

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