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Omecamtiv mecarbil-d8

Omecamtiv mecarbil-d8

Item no.	HY-14233S-1ea
Manufacturer	MedChem Express
Amount	1 ea
Quantity options	1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Morgan BP, et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett. 2010 Aug 20;1(9):472-7.\|[3]Mamidi R, et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol. 2015 Aug;85:262-72.\|[4]Swenson AM, et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292(9):3768-3778.
Smiles	O=C(N1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])CC2=C(C(NC(NC3=CC=C(N=C3)C)=O)=CC=C2)F)OC
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CK-1827452-d8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Isotope-Labeled Compounds; Myosin
Shipping Temperature	Room temperature
Molecular Weight	409.48
Product Description	Omecamtiv mecarbil-d8 is the deuterium labeled Omecamtiv mecarbil. Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.
Manufacturer - Research Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Cytoskeleton; Others
Clinical information	No Development Reported

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