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GRK6-IN-1

GRK6-IN-1

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-142812-5mg
CASRN	2677786-61-5
Available
Product Description	GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-Kinase/protease
Formula	C22H23ClN6O2
References	[1].Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13; 65(1):886-887]. J Med Chem. 2021; 64(15):11129-11147.
MolecularWeight	438.91
Research Area	Cancer
Solubility	DMSO : 50 mg/mL (113.92 mM; Need ultrasonic)
Target	Others
Pathway	Others

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Amount: 5mg

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Delivery expected until 4/20/2023

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