Comparison

GRK6-IN-1 European Partner

Item no. HY-142812-5mg
Manufacturer MedChem Express
CASRN 2677786-61-5
Amount 5 mg
Quantity options 100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.64
Formula C22H23ClN6O2
Citations [1]Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147.
Smiles COC1=CC=CC2=NC(NCC3=CC=C(Cl)C=C3OC)=NC(NC4=NNC(CC)=C4)=C12
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Shipping condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Cancer-Kinase/protease
Manufacturer - Targets
G Protein-coupled Receptor Kinase (GRK)
Shipping Temperature
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight
438.91
Product Description
GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma[1].
Manufacturer - Research Area
Cancer
Solubility
DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway
GPCR/G Protein
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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