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BLK-IN-2

BLK-IN-2

Item no.	HY-144288-50mg
Manufacturer	MedChem Express
CASRN	2694871-86-6
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.61
Citations	[1]Fu T, et, al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK). Eur J Med Chem. 2022 Feb 5;229:114051.
Smiles	O=C(C1=CC2=C(C=NC=C2)C=C1)NC3=CC=C(C)C(C(NC4=CN=C(NC5=CC=CC(NC6CCN(C(/C=C/CN(C)C)=O)CC6)=C5)N=C4)=O)=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Btk
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	683.80
Product Description	BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits BTK (IC50=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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HY-144288-50mg-safety-datasheet.pdf