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Methotrexate (disodium)

Methotrexate (disodium)

Item no.	HY-14519A-500mg
Manufacturer	MedChem Express
CASRN	7413-34-5
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.71
Citations	[1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73.\|[2]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.\|[3]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.\|[4]Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550. Sci Data. 2024 Sep 19.\|Acta Pharmacol Sin. 2021 Jan;42(1):108-114.\|Acta Pharmacol Sin. 2025 Feb 12.\|Anticancer Res. 2024 Jul;44(7):2787-2792.\|Anticancer Res. 2024 Oct;44(10):4213-4218.\|Arthritis Res Ther. 2022 Jan 19;24(1):27.\|Biochem Biophys Rep. December 2021, 101177.\|Biomed Pharmacother. 2024 Jul 19:178:117167.\|Biotechnol Bioeng. 2021 Sep 3.\|Cancers (Basel). 2022 Oct 19;14(20):5127.\|Cancers. 2019 Oct 25;11(11):1654.\|Cell Death Dis. 2020 Nov 12;11(11):976.\|Cell Death Dis. 2024 May 20;15(5):349.\|Cell Rep Methods. 2023 Oct 23;3(10):100599.\|Chem Res Toxicol. 2025 Feb 3.\|Commun Biol. 2022 Jun 23;5(1):619.\|Dis Model Mech. 2023 Mar 2;dmm.049769.\|EMBO Mol Med. 2022 Feb 17;e14552.\|Eur J Pharmacol. 2023 Nov 10:961:176162.\|Int Immunopharmacol. 2023 Feb;115:109689.\|Int Immunopharmacol. 2023 Nov 15;125(Pt B):111175.\|Int Immunopharmacol. 2024 May 4:134:112183.\|J Adv Res. 2024 Oct 5:S2090-1232(24)00432-6.\|J Biol Chem. 2019 Dec 27;294(52):20084-20096. \|J Bone Oncol. October 2021, 100391.\|J Clin Invest. 2023 May 30;e169993.\|J Exp Clin Cancer Res. 2024 Dec 26;43(1):330.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|J Nanobiotechnology. 2024 Mar 3;22(1):89.\|J Pharm Anal. 7 August 2022.\|Lung. 2024 Nov 27;203(1):4.\|Mediators Inflamm. 2024 Dec 5:2024:1995952.\|Micromachines. 2021 Jun 10;12(6):681.\|Mol Cancer. 2024 Apr 29;23(1):86.\|Mol Cancer. 2024 Jan 10;23(1):12.\|Nat Commun. 2025 Feb 28;16(1):2071.\|Oncotarget. 2017 Dec 2;8(68):112313-112329.\|Patent. US20170128439A1.\|Phytomedicine. 2022 Jun;100:154068.\|Plasma Process Polym. 2021 Feb 12.\|Queen’s University. Department of Biomedical Molecular Sciences. 2021 Oct.\|Redox Biol. 2024 Dec 25:79:103482.\|Research Square Preprint. 2023 Dec 1.\|Research Square Preprint. 2023 Dec 4.\|Sci Rep. 2018 Jun 21;8(1):9472. \|Sci Rep. 2024 Oct 31;14(1):26224.\|Sci Signal. 2024 Nov 26;17(864):eadp1375.\|Small. 2022 Jul;18(30):e2202337.\|Toxicology. 2020 May 15;437:152445.
Smiles	NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)C=C3)=N2)=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Amethopterin (disodium),CL14377 (disodium),WR19039 (disodium)
Similar products	7413-34-5
Shipping Condition	Room temperature
Available
Manufacturer - Type	ADC Related
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	ADC Cytotoxin; Antifolate; Apoptosis; Bacterial; DNA/RNA Synthesis
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	498.40
Product Description	Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 5 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Isoform	Traditional Cytotoxic Agents
Clinical information	Launched

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HY-14519A-500mg-safety-datasheet.pdf