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Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH

Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH

Item no.	HY-145254-100mg
Manufacturer	MedChem Express
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Citations	[1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. Published 2013 Jun 12.
Smiles	O=C(O)CCCC(NC(COCCC(NCCOCCOCCO[C@H]1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O1)=O)(COCCC(NCCOCCOCCO[C@H]2[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O2)=O)COCCC(NCCOCCOCCO[C@H]3[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O3)=O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Toll-like Receptor (TLR)
Shipping Temperature	Room temperature
Molecular Weight	1832.85
Product Description	Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Immunology/Inflammation
Clinical information	No Development Reported

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