« Back
Home /
m7GpppAmpG (ammonium)

m7GpppAmpG (ammonium)

Item no.	HY-145974A-1ea
Manufacturer	MedChem Express
Amount	1 ea
Quantity options	1.1 mg (100 mM x 10 uL in Water) 10 mg (100 mM x 87.8 uL in Water) 11.5 mg (100 mM x 100 uL in Water) 1 ea 5.7 mg (100 mM x 50 uL in Water) 5 mg (100 mM x 43.9 uL in Water)
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.50
Citations	[1]Sikorski PJ, Warminski M, Kubacka D, et al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020;48(4):1607-1626. \|[2]Zhang H, et al. GPT-Driven Generation and Biological Activity Evaluation of Novel mRNA Trinucleotide Cap1 Analogs for mRNA Vaccine or Immunotherapy. Journal of Materials Chemistry B, 2025.\|[3]Raab M, et al. Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer. Cancer Commun (Lond). 2024 Jan;44(1):101-126.
Smiles	O=P(O)(OC[C@@H]1[C@@H](OP(O)(OC[C@H]2O[C@@H](N3C(NC(N)=NC4=O)=C4N=C3)[C@H](O)[C@@H]2O)=O)[C@@H](OC)[C@H](N5C=NC6=C(N)N=CN=C65)O1)OP(OP(OC[C@H]7O[C@@H](N8C(NC(N)=N9)=C([N+](C)=C8)C9=O)[C@H](O)[C@@H]7O)([O])=O)(O)=O.[xNH3]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	m7G(5')ppp(5')(2'OMeA)pG ammonium
Shipping Condition	Cool pack
Available
Manufacturer - Type	Oligonucleotides
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA/RNA Synthesis; Eukaryotic Initiation Factor (eIF)
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Product Description	m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research[1][2][3].
Manufacturer - Research Area	Others
Solubility	10 mM in DMSO
Manufacturer - Pathway	Cell Cycle/DNA Damage
Isoform	eIF4
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-145974A-1ea-safety-datasheet.pdf