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P-gp inhibitor 4

P-gp inhibitor 4

Item no.	HY-146391-1ea
Manufacturer	MedChem Express
CASRN	2652001-05-1
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Contino M, et al. One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells. Eur J Med Chem. 2020 Dec 15;208:112843.
Smiles	COC1=CC=C(C=C1)S(=O)(N(S(=O)(C2=CC=C(C=C2)OC)=O)C3=CC=C(C=C3)C4=CC=C(C=C4)CN5CCC6=CC(OC)=C(C=C6C5)OC)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	P-glycoprotein
Shipping Temperature	Room temperature
Molecular Weight	714.85
Product Description	P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases agent transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Clinical information	No Development Reported

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