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Diltiazem (hydrochloride)

Diltiazem (hydrochloride)

Item no.	HY-14656-500mg
Manufacturer	MedChem Express
CASRN	33286-22-5
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Citations	[1]Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12.\|[2]van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63.\|[3]Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40.\|[4]Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40.\|[5]Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106. Pharmacol Res Perspect. 2020 Apr;8(2):e00575.\|Virology. 2020 Jan 2;539:38-48.\|J Cardiovasc Transl Res. 2023 Jan 30.\|Nat Commun. 2024 Jun 19.\|Pharmacol Res Perspect. 2021 Oct;9(5):e00879.
Smiles	CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(OC)C=C3)[C@@H](OC(C)=O)C1=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CRD-401
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	Calcium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	450.98
Product Description	Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	H2O: 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	L-type calcium channel
Clinical information	Launched

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HY-14656-500mg-safety-datasheet.pdf