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(S)-Thalidomide

(S)-Thalidomide

Item no.	HY-14658A-10mg
Manufacturer	MedChem Express
CASRN	841-67-8
Amount	10 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.65
Formula	C13H10N2O4
Citations	[1]Stephens TD. The effect of thalidomide in chicken embryos. Birth Defects Res A Clin Mol Teratol. 2009 Aug;85(8):725-31. [2]Murphy S, et al. Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. J Pharm Pharmacol. 2007 Jan;59(1):105-14. [3]Liu WM, et al. s-thalidomide has a greater effect on apoptosis than angiogenesis in a multiple myeloma cell line. Hematol J. 2004;5(3):247-54. [4]Tokunaga E, et al. Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers. Sci Rep. 2018 Nov 20;8(1):17131.
Smiles	O=C1N([C@@H](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(S)-(-)-Thalidomide
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	258.23
Product Description	(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects[1][2][3]. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) [4].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : 83.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; PROTAC
Isoform	Cereblon
Clinical information	No Development Reported

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HY-14658A-10mg-safety-datasheet.pdf