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UCB-5307

UCB-5307

Item no.	HY-147045-10mg
Manufacturer	MedChem Express
CASRN	1515887-44-1
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	97.09
Formula	C22H21N3O
Citations	[1]O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10(1):5795.
Smiles	OC(C1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2)C4=CC=NC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	TNF Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	343.42
Product Description	UCB-5307 is a potent TNF signaling inhibitor with a KD of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis
Isoform	TNFRSF5/CD40
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-147045-10mg-safety-datasheet.pdf