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UCB-5307

UCB-5307

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	HY-147045-10mg
CASRN	1515887-44-1
Available
Product Description	UCB-5307 is a potent TNF signaling inhibitor with a KD of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex.
StorageTemperature	4°C, sealed storage, away from moisture and light; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Applications	COVID-19-immunoregulation
Formula	C22H21N3O
References	[1].O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19; 10(1):5795.
MolecularWeight	343.42
Research Area	Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (145.59 mM; Need ultrasonic)
Target	TNF Receptor
Pathway	Apoptosis

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Amount: 10mg

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Delivery expected until 4/20/2023

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