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Nelutroctiv

Nelutroctiv

Item no.	HY-147292-10mg
Manufacturer	MedChem Express
CASRN	2299177-09-4
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.57
Citations	[1]Jani V P, et al. The small-molecule troponin activator CK-136 increases myocyte contractility in human heart failure. Biophysical Journal, 2024, 123(3): 402a. \|[2]Romero A, et al. Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility. J Med Chem. 2024 May 23;67(10):7825-7835.
Smiles	O=C(C1=CN=CC(S(C)(=O)=O)=C1)N2[C@@]3([H])[C@](C[C@@H]2C(N[C@H](C4CC4)C5=C(C=C(C(F)=C5)C(F)(F)F)F)=O)([H])C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CK-136
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Calcium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	543.51
Product Description	Nelutroctiv (CK-136) is an orally active and selective cardiac troponin activator. Nelutroctiv activates cardiac sarcomeres by enhancing the sensitivity of troponin to calcium ions and promoting the interaction between actin and myosin. Nelutroctiv enhances cardiac contractility. Nelutroctiv can be used in the researches for cardiovascular diseases with impaired cardiac contractile function[1][2].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	No Development Reported

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HY-147292-10mg-safety-datasheet.pdf