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PCLX-001

PCLX-001

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-147308-5mg
CASRN	1215011-08-7
Available
Product Description	PCLX-001 is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. PCLX-001 exhibits anti-tumor activity and inhibits early B-cell receptor (BCR) signaling, can be used to B-cell malignancies research.
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Cancer-programmed cell death
Formula	C24H30Cl2N6O2S
References	[1].Michael Weickert, et al. Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies. Blood. 2019. 134(s1):3362. \| [2].Beauchamp E, et al. Targeting N-myristoylation for therapy of B-cell lymphomas. Nat Commun. 2020 Oct 22; 11(1):5348.
MolecularWeight	537.51
Research Area	Cancer
Target	DNA/RNA Synthesis
Pathway	Cell Cycle/DNA Damage

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 5mg

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Delivery expected until 4/13/2023

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