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POLA1 inhibitor 1

POLA1 inhibitor 1

Item no.	HY-147812-50mg
Manufacturer	MedChem Express
CASRN	2217671-41-3
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.85
Citations	[1]Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253.
Smiles	O=C(O)/C=C/C1=CC=C(C2=CC=C(O)C(C34CC5CC(C4)CC(C5)C3)=C2)C(/C=N/O)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA/RNA Synthesis
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	417.50
Product Description	POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 180 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	No Development Reported

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HY-147812-50mg-safety-datasheet.pdf