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Givinostat

Givinostat

Item no.	HY-14842-25mg
Manufacturer	MedChem Express
CASRN	497833-27-9
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.67
Citations	[1]Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.\|[2]Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.\|[3]Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15. Acta Pharmacol Sin. 2021 Apr 13.\|bioRxiv. 2025 January 15.\|Cell Prolif. 2021 May 24;e13072.\|Commun Biol. 2021 Oct 29;4(1):1235.\|J Am Chem Soc. 2024 Sep 27.\|J Orthop Transl. 29 (2021) 106-112.\|Neuroscience. 2021 Apr 13;S0306-4522(21)00185-8.\|Patent. US20240252638A1.\|SSRN. 2024 Mar 13.\|Cell Death Dis. 2020 Sep 15;11(9):753.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
Smiles	O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ITF-2357
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	HDAC
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	421.49
Product Description	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research[1].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 200 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics
Isoform	HD1; HD2; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-14842-25mg-safety-datasheet.pdf