Comparison

Tonapofylline European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 100mg
Item no. HY-14873-100mg
CASRN 340021-17-2
Available
Product Description
Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.
StorageTemperature
Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications
Neuroscience-Neuromodulation
Formula
C22H32N4O4
References
[1].Kiesman WF, et al. Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. J Med Chem. 2006 Nov 30; 49(24):7119-31. | [2].Ensor CR, et al. Tonapofylline: a selective adenosine-1 receptor antagonist for the treatment of heart failure. Expert Opin Pharmacother. 2010 Oct; 11(14):2405-15. | [3].Gill A, et al. Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against NSC 119875-induced acute kidney injury in rats. Am J Nephrol. 2009; 30(6):521-6.
MolecularWeight
416.51
Research Area
Metabolic Disease; Cardiovascular Disease
Solubility
DMSO : 100 mg/mL (240.09 mM; Need ultrasonic)
Target
Adenosine Receptor
Pathway
GPCR/G Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 100mg
Available: In stock
available

Delivery expected until 4/13/2023 

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