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Tonapofylline

Tonapofylline

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-14873-100mg
CASRN	340021-17-2
Available
Product Description	Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Neuroscience-Neuromodulation
Formula	C22H32N4O4
References	[1].Kiesman WF, et al. Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. J Med Chem. 2006 Nov 30; 49(24):7119-31. \| [2].Ensor CR, et al. Tonapofylline: a selective adenosine-1 receptor antagonist for the treatment of heart failure. Expert Opin Pharmacother. 2010 Oct; 11(14):2405-15. \| [3].Gill A, et al. Protective effect of tonapofylline (BG9928), an adenosine A1 receptor antagonist, against NSC 119875-induced acute kidney injury in rats. Am J Nephrol. 2009; 30(6):521-6.
MolecularWeight	416.51
Research Area	Metabolic Disease; Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (240.09 mM; Need ultrasonic)
Target	Adenosine Receptor
Pathway	GPCR/G Protein

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Amount: 100mg

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Delivery expected until 4/13/2023

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