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5-Aminosalicylic Acid-d3 (hydrochloride)

5-Aminosalicylic Acid-d3 (hydrochloride)

Item no.	HY-15027S-1mg
Manufacturer	MedChem Express
CASRN	1346601-18-0
Amount	1 mg
Quantity options	10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.00
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.;Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 28;13(20):2872-7.;Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov;34(11):2580-6.
Smiles	OC(C1=C(C([2H])=C([2H])C(N)=C1[2H])O)=O.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Mesalamine-D3 (hydrochloride),5-ASA-D3 (hydrochloride),Mesalazine-D3 (hydrochloride)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Endogenous Metabolite; Isotope-Labeled Compounds; NF-κB; PAK; PPAR
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light)
Molecular Weight	192.61
Product Description	5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported

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HY-15027S-1mg-safety-datasheet.pdf