Comparison

MLN120B dihydrochloride European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 25mg
Item no. HY-15473A-25mg
CASRN 1782573-78-7
Available
Product Description
MLN120B dihydrochloride (ML120B dihydrochloride) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis.
StorageTemperature
4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications
COVID-19-immunoregulation
Formula
C19H17Cl3N4O2
References
[1].Hideshima T, et all. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res. 2006 Oct 1; 12(19):5887-94. | [2].Schopf L, et al. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum. 2006 Oct; 54(10):3163-73. | [3].Ansaldi D, et al. Imaging pulmonary NF-kappaB activation and therapeutic effects of MLN120B and TDZD-8. PLoS One. 2011; 6(9):e25093. | [4].[3].Nagashima K, et al. Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood. 2006 Jun 1; 107(11):4266-73.
MolecularWeight
439.72
Research Area
Cancer; Inflammation/Immunology
Solubility
DMSO : 16.67 mg/mL (37.91 mM; ultrasonic and warming and adjust pH to 8 with NaOH and heat to 80°C)
Target
IKK
Pathway
NF-κB

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 25mg
Available: In stock
available

Delivery expected until 4/6/2023 

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