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Olverembatinib

Olverembatinib

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	25mg
Item no.	HY-15666-25mg
CASRN	1257628-77-5
Available
Product Description	Olverembatinib (GZD824) is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib strongly inhibits native Bcr-Abl and Bcr-AblT315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib has antitumor activity.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-Kinase/protease
Formula	C29H27F3N6O
References	[1].Ren X, Pan X, Zhang Z, Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. J Med Chem. 2013 Feb 14; 56(3):879-94.
MolecularWeight	532.56
Research Area	Cancer
Solubility	DMSO : 50 mg/mL (93.89 mM; Need ultrasonic)
Target	Bcr-Abl
Pathway	Protein Tyrosine Kinase/RTK

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Amount: 25mg

available

Delivery expected until 4/13/2023

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