Comparison

H-1152 dihydrochloride European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 100mg
Item no. HY-15720A-100mg
CASRN 871543-07-6
Available
Product Description
H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
StorageTemperature
4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications
Neuroscience-Neuromodulation
Formula
C16H23Cl2N3O2S
References
[1].Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):245-52. Epub 2005 Sep 12. | [2].Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr; 81(1):9-16. | [3].Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25; 169(2):855-62.
MolecularWeight
392.34
Research Area
Neurological Disease
Solubility
DMSO : 50 mg/mL (127.44 mM; Need ultrasonic) | H2O : 35.71 mg/mL (91.02 mM; Need ultrasonic)
Target
ROCK
Isoform
ROCKII; CaMKII; PKG; AuroraA; PKA; Src; PKC; Abl; MKK4; MLCK; EGFR; GSK3α; AMPK; P38α
Pathway
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 100mg
Available: In stock
available

Delivery expected until 4/6/2023 

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