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H-1152 dihydrochloride

H-1152 dihydrochloride

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-15720A-100mg
CASRN	871543-07-6
Available
Product Description	H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
StorageTemperature	4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications	Neuroscience-Neuromodulation
Formula	C16H23Cl2N3O2S
References	[1].Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):245-52. Epub 2005 Sep 12. \| [2].Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr; 81(1):9-16. \| [3].Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25; 169(2):855-62.
MolecularWeight	392.34
Research Area	Neurological Disease
Solubility	DMSO : 50 mg/mL (127.44 mM; Need ultrasonic) \| H2O : 35.71 mg/mL (91.02 mM; Need ultrasonic)
Target	ROCK
Isoform	ROCKII; CaMKII; PKG; AuroraA; PKA; Src; PKC; Abl; MKK4; MLCK; EGFR; GSK3α; AMPK; P38α
Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

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Amount: 100mg

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Delivery expected until 4/6/2023

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