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H-1152 (dihydrochloride)

H-1152 (dihydrochloride)

Item no.	HY-15720A-100mg
Manufacturer	MedChem Express
CASRN	871543-07-6
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.09
Formula	C16H23Cl2N3O2S
Citations	Research Square Preprint. 2021 Jun. Acta Neuropathol Commun. 2024 Sep 14;12(1):150. [1]Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12. [2]Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81(1):9-16. [3]Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169(2):855-62.
Smiles	CC1=CN=CC2=C1C(S(=O)(N3[C@@H](C)CNCCC3)=O)=CC=C2.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	ROCK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Product Description	H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 35.71 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Isoform	ROCK2
Clinical information	No Development Reported

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HY-15720A-100mg-safety-datasheet.pdf