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Ranolazine-d8 (dihydrochloride)

Ranolazine-d8 (dihydrochloride)

Item no.	HY-17401S-1ea
Manufacturer	MedChem Express
CASRN	1219802-60-4
Amount	1 ea
Quantity options	1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.0
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013 Jan;73(1):55-73.\|[3]Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81. doi: 10.1124/jpet.108.137729. Epub 2008 Mar 5.\|[4]Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.
Smiles	CC(C=CC=C1C)=C1NC(CN(C([2H])([2H])C2([2H])[2H])C([2H])([2H])C([2H])([2H])N2CC(O)COC3=C(C=CC=C3)OC)=O.[H]Cl.[H]Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CVT 303-d8 (dihydrochloride),RS 43285-d8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Autophagy; Calcium Channel; Sodium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	508.51
Product Description	Ranolazine-d8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	10 mM in DMSO\|DMSO: ≥ 50mg/mL\|H2O: ≥ 50mg/mL
Manufacturer - Pathway	Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	No Development Reported

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