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Capreomycin (sulfate)

Capreomycin (sulfate)

Item no.	HY-17566-500mg
Manufacturer	MedChem Express
CASRN	1405-37-4
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.52
Citations	[1]Maus CE, et al. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2005 Feb;49(2):571-7.\|[2]Garcia-Contreras L, et al. Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother. 2007 Aug;51(8):2830-6.\|[3]Siddiqi M K, et al. Capreomycin inhibits the initiation of amyloid fibrillation and suppresses amyloid induced cell toxicity[J]. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2018, 1866(4): 549-557.\|[4]Reisfeld B, et al. A physiologically based pharmacokinetic model for capreomycin[J]. Antimicrobial agents and chemotherapy, 2012, 56(2): 926-934.\|[5]Le Conte P, et al. Pharmacokinetics, toxicity, and efficacy of liposomal capreomycin in disseminated Mycobacterium avium beige mouse model[J]. Antimicrobial agents and chemotherapy, 1994, 38(12): 2695-2701.
Smiles	N[C@@H](CNC([C@H]([C@H]1CCNC(N1)=N)NC(/C2=C/NC(N)=O)=O)=O)C(N[C@@H](CO)C(N[C@H](C(N2)=O)CN)=O)=O.O=S(O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1405-37-4
Shipping Condition	Cool pack
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Bacterial
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	638.61
Product Description	Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease[1][2][3][4][5].
Manufacturer - Research Area	Infection; Metabolic Disease; Neurological Disease
Solubility	H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection
Isoform	Aminoglycoside
Clinical information	Launched

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HY-17566-500mg-safety-datasheet.pdf