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BI-9627

BI-9627

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	HY-18071-10mg
CASRN	1204329-34-9
Available
Product Description	BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Neuroscience-Neuromodulation
Formula	C16H19F3N4O2
References	[1].Huber JD, et al. Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitableprofile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J Med Chem. 2012 Aug 23; 55(16):7114-40.
MolecularWeight	356.34
Research Area	Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (280.63 mM; Need ultrasonic)
Target	Na+/H+ Exchanger (NHE)
Pathway	Membrane Transporter/Ion Channel

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Amount: 10mg

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Delivery expected until 4/20/2023

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