Comparison

BI-9627 European Partner

Item no. HY-18071-10mg
Manufacturer MedChem Express
CASRN 1204329-34-9
Amount 10 mg
Quantity options 100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.0
Formula C16H19F3N4O2
Citations Cell Rep. 2024 Dec 12;43(12):115065.
Hum Reprod. 2024 Feb 14:deae020.
[1]Huber JD, et al. Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitableprofile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J Med Chem. 2012 Aug 23;55(16):7114-40.
Smiles NC(NC(C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1)=O)=N
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Shipping condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Neuroscience-Neuromodulation
Manufacturer - Targets
Na+/H+ Exchanger (NHE)
Shipping Temperature
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight
356.34
Product Description
BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1].
Manufacturer - Research Area
Cardiovascular Disease
Solubility
DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway
Membrane Transporter/Ion Channel
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
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