KIRA6

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-19708-100mg
CASRN	1589527-65-0
Available
Product Description	KIRA6 is an advanced small-molecule IRE1α RNase kinase inhibitor with an IC50 of 0.6 µM. KIRA6 can trigger an apoptotic response.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-Kinase/protease
Formula	C28H25F3N6O
References	[1].Mahameed M, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019 Apr 1; 10(4):300. \| [2].Ghosh R, et al. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48.
MolecularWeight	518.53
Research Area	Cancer; Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (48.21 mM; Need ultrasonic)
Target	IRE1
Pathway	Cell Cycle/DNA Damage

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Amount: 100mg

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Delivery expected until 4/6/2023

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