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NSC45586 (sodium)

NSC45586 (sodium)

Item no.	HY-19820A-50mg
Manufacturer	MedChem Express
CASRN	6300-44-3
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C20H17N6NaO3
Citations	[1]Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.
Smiles	O=C(O[Na])C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Akt; Ser/Thr Protease
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Product Description	NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].
Manufacturer - Research Area	Cancer; Neurological Disease
Solubility	H2O : 5 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Clinical information	No Development Reported

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HY-19820A-50mg-safety-datasheet.pdf