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Contezolid acefosamil (sodium)

Contezolid acefosamil (sodium)

Item no.	HY-19915B-5mg
Manufacturer	MedChem Express
CASRN	1807365-35-0
Amount	5 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	95.19
Dry ice	Yes
Citations	[1]Junzhen Wu, et al. Evaluation of the Effect of Contezolid (MRX-I) on the Corrected QT Interval in a Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study in Healthy Chinese Volunteers. Antimicrob Agents Chemother. 2020 May 21;64(6):e02158-19.\|[2]Mikhail F Gordeev, et al. New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. J Med Chem. 2014 Jun 12;57(11):4487-97.\|[3]Carolyn Shoen, et al. In Vitro and In Vivo Activities of Contezolid (MRX-I) against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00493-18.
Smiles	FC(C(F)=C1N(C=C2)CCC2=O)=C(N(C(O3)=O)C[C@@H]3CN(C4=NOC=C4)[P](OC(C)=O)(O[Na])=O)C=C1F
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	MRX-4 (sodium)
Shipping Condition	Dry ice
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Bacterial; Monoamine Oxidase
Shipping Temperature	Dry Ice
Storage Conditions	-80°C, stored under nitrogen
Molecular Weight	552.33
Product Description	Contezolid acefosamil sodium (MRX-4), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid acefosamil sodium (MRX-4) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI)[1][2].
Manufacturer - Research Area	Infection; Inflammation/Immunology
Solubility	DMSO: 180 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Neuronal Signaling
Isoform	Oxazolidinone
Clinical information	Phase 1

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HY-19915B-5mg-safety-datasheet.pdf