Comparison

Pifusertib European Partner

Item no. HY-19934-10mg
Manufacturer MedChem Express
CASRN 1402602-94-1
Amount 10 mg
Quantity options 10 mg 1 ea 25 mg 50 mg 5 mg
Category
Type Molecules
Specific against other
Citations [1]Mimura N, et al. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res. 2014;74(16):4458-4469.
Smiles C[C@@](C1)(O)C[C@]1(N)C2=CC=C(C3=C(N(COC4=CC=NC=C45)C5=N3)C6=CC=CC=C6)C=C2
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Alias TAS-117
Shipping Condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Cancer-Kinase/protease
Manufacturer - Targets
Akt; Apoptosis; Autophagy
Shipping Temperature
Room temperature
Molecular Weight
424.49
Product Description
Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy[1].
Manufacturer - Research Area
Cancer
Solubility
10 mM in DMSO
Manufacturer - Pathway
Apoptosis; Autophagy; PI3K/Akt/mTOR
Isoform
Akt1; Akt2; Akt3
Clinical information
Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
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