RO-3

Item no.	HY-19978-10mg
Manufacturer	MedChem Express
CASRN	1026582-88-6
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	97.32
Citations	[1]Ford AP, et al. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol. 2006;147 Suppl 2(Suppl 2):S132-S143.
Smiles	NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C(C)C)C(N)=N1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	P2X Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	302.37
Product Description	RO-3 is a potent, CNS-penetrant, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 μM at P2X1, 2, 4, 5, 7)[1].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 125 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Isoform	P2X2 Receptor; P2X3 Receptor
Clinical information	No Development Reported

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HY-19978-10mg-safety-datasheet.pdf