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Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP

Item no.	HY-20336-250mg
Manufacturer	MedChem Express
CASRN	159857-81-5
Amount	250 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 1 g 200 mg 250 mg 500 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.89
Formula	C35H43N7O11
Citations	[1]Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2. [2]Li Y, et al. Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575.
Smiles	CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
Shipping condition	Room temperature
Available
Manufacturer - Type	ADC Related
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	ADC Linker
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	737.76
Product Description	Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs[1][2].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Others
Solubility	DMSO : ≥ 37 mg/mL
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related
Isoform	Cleavable Linker; Protease Cleavable Linker
Clinical information	No Development Reported

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HY-20336-250mg-safety-datasheet.pdf