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GDC-0879

GDC-0879

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-50864-100mg
CASRN	905281-76-7
Available
Product Description	GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-Kinase/protease
Formula	C19H18N4O2
References	[1].Hansen JD, et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15; 18(16):4692-5. \| [2].Wong H, et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2, 3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr; 329(1):360-7.
MolecularWeight	334.37
Research Area	Cancer
Solubility	DMSO : 50 mg/mL (149.53 mM; Need ultrasonic)
Target	Raf
Isoform	B-Raf
Pathway	MAPK/ERK Pathway

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Amount: 100mg

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Delivery expected until 4/13/2023

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