Comparison

GDC-0879 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 100mg
Item no. HY-50864-100mg
CASRN 905281-76-7
Available
Product Description
GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.
StorageTemperature
Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications
Cancer-Kinase/protease
Formula
C19H18N4O2
References
[1].Hansen JD, et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15; 18(16):4692-5. | [2].Wong H, et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2, 3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr; 329(1):360-7.
MolecularWeight
334.37
Research Area
Cancer
Solubility
DMSO : 50 mg/mL (149.53 mM; Need ultrasonic)
Target
Raf
Isoform
B-Raf
Pathway
MAPK/ERK Pathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 100mg
Available: In stock
available

Delivery expected until 4/13/2023 

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