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Lomibuvir

Lomibuvir

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	100 mg
Item no.	HY-75800-100mg
CASRN	1026785-55-6
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	445.6147
Clinical_Information	Phase 2
Manufacturers Research_Area	Infection
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target	DNA/RNA Synthesis; HCV
Pathway	Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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