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Amlodipine

Amlodipine

Item no.	HY-B0317-500mg
Manufacturer	MedChem Express
CASRN	88150-42-9
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.87
Citations	[1]Kishen G. Bulsara, et al. Amlodipine.\|[2]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.\|[3]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.\|[4]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.\|Cells. 2022 Oct 8;11(19):3156.\|Exp Mol Med. 2021 Apr 2.\|Food Chem Toxicol. 2025 Feb 10:115317.\|J Adv Res. 2023 Sep 13;S2090-1232(23)00257-6.\|J Biochem Mol Toxicol. 2022 Oct 7;e23238.\|J Chem Thermodyn. 2021, 106495.\|Nat Prod Commun. 2024 Mar 20.\|Br J Pharmacol. 2021 Dec 3.\|Dissolut Technol. 2021 Jun.\|Sci Adv. 2025 Jan 24;11(4):eadp4765.
Smiles	O=C(OCC)C1=C(NC(C)=C(C1C2=CC=CC=C2Cl)C(OC)=O)COCCN
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	88150-42-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Calcium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	408.88
Product Description	Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].
Manufacturer - Research Area	Cancer; Cardiovascular Disease
Solubility	DMSO: 31.25 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	L-type calcium channel
Clinical information	Launched

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HY-B0317-500mg-safety-datasheet.pdf