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Nicorandil

Nicorandil

Item no.	HY-B0341-100mg
Manufacturer	MedChem Express
CASRN	65141-46-0
Amount	100 mg
Quantity options	100 mg 10mM/1mL 50 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Heart Failure Myocardial Infarction Hypertension Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.20
Formula	C8H9N3O4
Citations	[1]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25. [2]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9. [3]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65(5):1198-207.
Smiles	O=C(C1=CC=CN=C1)NCCO[N+]([O-])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SG-75
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	211.17
Product Description	Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	DMSO : ≥ 33 mg/mL\|H2O : ≥ 20 mg/mL
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Clinical information	Launched

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HY-B0341-100mg-safety-datasheet.pdf