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Dyclonine (hydrochloride)

Dyclonine (hydrochloride)

Item no.	HY-B0364A-500mg
Manufacturer	MedChem Express
CASRN	536-43-6
Amount	500 mg
Quantity options	10 g 10 mM/1 mL 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.30
Citations	[1]Okazaki S, et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9(73):33832-33843. \|[2]FLORESTANO HJ, et al. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc. 1956 May;45(5):320-5. \|[3]Khanna M, et al. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem. 2011 Dec 16;286(50):43486-94.
Smiles	O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Dyclocaine hydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Aldehyde Dehydrogenase (ALDH); Bacterial; Fungal
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	325.87
Product Description	Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[1][2][3].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: ≥ 25 mg/mL\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Metabolic Enzyme/Protease
Isoform	ALDH2; ALDH3
Clinical information	Launched

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HY-B0364A-500mg-safety-datasheet.pdf