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Naftopidil

Naftopidil

Item no.	HY-B0391-1g
Manufacturer	MedChem Express
CASRN	57149-07-2
Amount	1 g
Quantity options	10 g 10 mM/1 mL 1 g 500 mg 5 g
Category	Oncology By Cell Type Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.47
Citations	[1]Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.\|[2]R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.
Smiles	OC(CN1CCN(C(C=CC=C2)=C2OC)CC1)COC3=CC=CC4=CC=CC=C34
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	KT-611,BM-15275
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Adrenergic Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	392.49
Product Description	Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia[1][2].
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology
Solubility	DMSO: 33.33 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	α adrenergic receptor
Clinical information	Launched

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HY-B0391-1g-safety-datasheet.pdf