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Tolbutamide

Tolbutamide

Item no.	HY-B0401-500mg
Manufacturer	MedChem Express
CASRN	64-77-7
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Sánchez‐Alvarez R, et al. Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up‐regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation [J]. Glia, 2006, 54(2): 125-134.\|[2]Hœy M, et al. Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial‐like ATP‐sensitive K+ (KATP) conductance in rat pancreatic A‐cells [J]. The Journal of Physiology, 2000, 527(1): 109-120.\|[3]Williams A J K, et al. Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse [J]. Diabetologia, 1993, 36: 487-492.\|[4]Belisle R J, et al. Tolbutamide treatment of pregnant mice: repeated administration reduces fetal lethality [J]. Teratology, 1976, 13(1): 65-70.
Smiles	O=S(C1=CC=C(C)C=C1)(NC(NCCCC)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	64-77-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Na+/K+ ATPase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	270.35
Product Description	Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete[1][2][3][4].
Manufacturer - Research Area	Metabolic Disease; Cancer
Solubility	DMSO: ≥ 34 mg/mL
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Clinical information	Launched

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HY-B0401-500mg-safety-datasheet.pdf