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Tolbutamide-d9

Tolbutamide-d9

Item no.	HY-B0401S-5mg
Manufacturer	MedChem Express
CASRN	1219794-57-6
Amount	5 mg
Quantity options	10 mg 1 mg 2.5 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.02
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Wray, H.L. and A.W. Harris, Adenosine 3', 5'-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4.\|[3]Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34.
Smiles	O=S(C1=CC=C(C)C=C1)(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Autophagy; Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	279.40
Product Description	Tolbutamide-d9 is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
Manufacturer - Research Area	Metabolic Disease; Cancer
Solubility	10 mM in DMSO\|DMF: ≥ 30mg/mL\|DMSO: ≥ 30mg/mL\|Ethanol: ≥ 30mg/mL
Manufacturer - Pathway	Autophagy; Membrane Transporter/Ion Channel
Clinical information	No Development Reported

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HY-B0401S-5mg-safety-datasheet.pdf