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Amantadine

Amantadine

Item no.	HY-B0402-10mM
Manufacturer	MedChem Express
CASRN	768-94-5
Amount	10 mM x 1 mL
Quantity options	100 g 10 g 10 mM x 1 mL 1 g 25 g 500 mg 50 g 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.90
Citations	[1]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.\|[2]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.\|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. \|[4]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. \|[5]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85.\|[6]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. SSRN. 2024 Aug 7.\|Chem Phys Lipids. 2024 May 11:262:105397.\|Int J Nanomedicine. 2019 Nov 27;14:9217-9234.\|Signal Transduct Target Ther. 2021 Mar 27;6(1):134.
Smiles	NC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1-Adamantanamine,1-Aminoadamantane
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	Apoptosis; Bcl-2 Family; CDK; Influenza Virus; Orthopoxvirus; SARS-CoV
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	151.25
Product Description	Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
Manufacturer - Research Area	Cancer; Infection; Neurological Disease
Solubility	DMSO: 6.48 mg/mL (ultrasonic; warming; adjust pH to 4 with 1 M HCl; heat to 60°C)
Manufacturer - Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Isoform	Bax; Bcl-2; CDK2
Clinical information	Launched

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HY-B0402-10mM-safety-datasheet.pdf