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Probenecid-d14

Probenecid-d14

Item no.	HY-B0545S-10mg
Manufacturer	MedChem Express
CASRN	1189657-87-1
Amount	10 mg
Quantity options	10 mg 1 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.0
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.\|[2]Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44.\|[3]Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8.\|[4]Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123.\|[5]Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7.
Smiles	S(N(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(=O)(=O)C1=CC=C(C(O)=O)C=C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Bacterial; HIV; Isotope-Labeled Compounds; TRP Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	299.45
Product Description	Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: 30 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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