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Fipronil

Fipronil

Manufacturer	MedChem Express
Category	Food Safety Pesticides Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10mM/1mL
Item no.	HY-B0822-10mM
CASRN	120068-37-3
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes[1][2].
StorageTemperature	4°C (Powder, protect from light, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	437.15
Clinical_Information	Launched
Manufacturers Research_Area	Neurological Disease
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Cytochrome P450; GABA Receptor
Isoform	CYP1; CYP2; CYP3
Pathway	Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Reference compound

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