Comparison

Escin European Partner

Item no. HY-B2114-100mg
Manufacturer MedChem Express
CASRN 6805-41-0
Amount 100 mg
Quantity options 100 mg 10 mM/1 mL 10 mg
Category
Type Inhibitors
Specific against other
Purity 95.0
Formula C55H86O24
Citations [1]Sipos W, et al. Escin inhibits type I allergic dermatitis in a novel porcine model. Int Arch Allergy Immunol. 2013;161(1):44-52.
[2]Sun X, et al. Escin avoids hemorrhagic transformation in ischemic stroke by protecting BBB through the AMPK/Cav-1/MMP-9 pathway. Phytomedicine. 2023 Nov;120:155071.
[3]Elshal M, Hazem SH. Escin suppresses immune cell infiltration and selectively modulates Nrf2/HO-1, TNF-α/JNK, and IL-22/STAT3 signaling pathways in concanavalin A-induced autoimmune hepatitis in mice. Inflammopharmacology. 2022 Dec;30(6):2317-2329.
[4]Suryavanshi SV, Kulkarni YA. Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats. Life Sci. 2020 Aug 1;254:117777.
[5]Wang Z, et al. Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway. Acta Pharmacol Sin. 2018 Oct;39(10):1645-1660.
[6]Cheng CL, et al. Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study. Eur J Pharmacol. 2018 Dec 5;840:79-88.
Smiles OC[C@]12[C@](CC(C)([C@H]([C@@H]2OC(C)=O)[R])C)([H])C3=CC[C@@]([C@@]4([C@@]([C@](C)([C@H](CC4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)C(O)=O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)CO)([H])CC8)C)([H])[C@]8(C)[C@@]3(C[C@H]1O)C.CC(OC[C@]9%10[C@](CC(C)([C@H]([C@@H]%10O)[R])C)([H])C%11=CC[C@@]([C@@]%12([C@@]([C@](C)([C@H](CC%12)O[C@H]%13[C@@H]([C@H]([C@@H]([C@H](O%13)C(O)=O)O[C@@H]%14O[C@@H]([C@H]([C@@H]([C@H]%14O)O)O)CO)O)O[C@@H]%15O[C@@H]([C@H]([C@@H]([C@H]%15O)O)O)CO)CO)([H])CC%16)C)([H])[C@]%16(C)[C@@]%11(C[C@H]9O)C)=O.[O]C(/C(C)=C\C)=O.[O]C(/C(C)=C/C)=O.[O]C(/C(C)=C\C)=O.[O]C(/C(C)=C/C)=O.[Aescin A].[Aescin B].[(E)].[(Z)].[Aescin C].[Aescin D].[(Z)].[(E)]
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Shipping condition Room temperature
Available
Manufacturer - Type
Natural Products
Manufacturer - Applications
COVID-19-immunoregulation
Manufacturer - Targets
Apoptosis
Shipping Temperature
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Description
Escin, a natural compound of triterpenoid saponins that can be isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].
Manufacturer - Research Area
Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
DMSO : 1.92 mg/mL (ultrasonic; warming; heat to 60°C)|H2O : < 0.1 mg/mL
Manufacturer - Pathway
Apoptosis
Clinical information
Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close