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Glycylglycine

Glycylglycine

Item no.	HY-D0889-500mg
Manufacturer	MedChem Express
CASRN	556-50-3
Amount	500 mg
Quantity options	10 mM/1 mL 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Xu B, et al. Glycylglycine plays critical roles in the proliferation of spermatogonial stem cells. Mol Med Rep. 2019 Oct;20(4):3802-3810.\|[2]Zhao C, et al. Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects. J Pharm Biomed Anal. 2015 Nov 10;115:48-54.
Smiles	O=C(O)CNC(CN)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	556-50-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	RT, protect from light
Molecular Weight	132.12
Product Description	Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis)[1][2].
Manufacturer - Research Area	Metabolic Disease
Solubility	Acetone: < 1 mg/mL\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	No Development Reported

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HY-D0889-500mg-safety-datasheet.pdf